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Issue 2, 2011
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Time and space resolved uptake study of silica nanoparticles by human cells

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Abstract

A spatio-temporal mapping of the uptake of silica (SiO2) nanoparticles of different sizes by lung epithelial cells has been obtained. Based on high control of nanoparticle dispersion in cell media and cell exposure, one obtains reproducible and quantitative time-resolved data using a combination of flow cytometry, fluorescence and electron microscopies. We are thereby able to give a rather detailed account of the journey of SiO2 nanoparticles from the early events of uptake to their final sub-cellular localization.

Graphical abstract: Time and space resolved uptake study of silica nanoparticles by human cells

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Publication details

The article was received on 21 Jul 2010, accepted on 01 Sep 2010 and first published on 29 Sep 2010


Article type: Paper
DOI: 10.1039/C0MB00109K
Citation: Mol. BioSyst., 2011,7, 371-378
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    Time and space resolved uptake study of silica nanoparticles by human cells

    K. Shapero, F. Fenaroli, I. Lynch, D. C. Cottell, A. Salvati and K. A. Dawson, Mol. BioSyst., 2011, 7, 371
    DOI: 10.1039/C0MB00109K

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