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Issue 19, 2011
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A digital microfluidic method for dried blood spot analysis

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Abstract

Blood samples stored as dried blood spots (DBSs) are emerging as a useful sampling and storage vehicle for a wide range of applications. Unfortunately, the surging popularity of DBS samples has not yet been accompanied by an improvement in automated techniques for extraction and analysis. As a first step towards overcoming this challenge, we have developed a prototype microfluidic system for quantification of amino acids in dried blood spots, in which analytes are extracted, mixed with internal standards, derivatized, and reconstituted for analysis by (off-line and in-line) tandem mass spectrometry. The new method is fast, robust, precise, and most importantly, compatible with automation. We propose that the new method can potentially contribute to a new generation of analytical techniques for quantifying analytes in DBS samples for a wide range of applications.

Graphical abstract: A digital microfluidic method for dried blood spot analysis

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Publication details

The article was received on 15 Jun 2011, accepted on 03 Aug 2011 and first published on 25 Aug 2011


Article type: Paper
DOI: 10.1039/C1LC20524B
Citation: Lab Chip, 2011,11, 3218-3224
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    A digital microfluidic method for dried blood spot analysis

    M. J. Jebrail, H. Yang, J. M. Mudrik, N. M. Lafrenière, C. McRoberts, O. Y. Al-Dirbashi, L. Fisher, P. Chakraborty and A. R. Wheeler, Lab Chip, 2011, 11, 3218
    DOI: 10.1039/C1LC20524B

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