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Issue 19, 2011
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Rapid mixing of sub-microlitre drops by magnetic micro-stirring

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We demonstrate rapid mixing of sub-microlitre droplets (250 nl) using miniaturized magnetic stir bars (400 μm × 200 μm × 15 μm). The stir bars are fabricated using laser micromachining and placed on the substrate on which the drops are manipulated. They are activated by an externally applied magnetic field and used in combination with on-demand drop merging in enthalpy arrays. This technique results in a 10-fold increase in mixing rate, and a mixing time constant of about 2 s. Drop mixing times are measured by Förster resonance energy transfer (FRET) and verified by thermodynamic measurements of binding and enzymatic reactions.

Graphical abstract: Rapid mixing of sub-microlitre drops by magnetic micro-stirring

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Publication details

The article was received on 26 Apr 2011, accepted on 18 Jul 2011 and first published on 15 Aug 2011

Article type: Paper
DOI: 10.1039/C1LC20354A
Citation: Lab Chip, 2011,11, 3313-3319

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    Rapid mixing of sub-microlitre drops by magnetic micro-stirring

    D. De Bruyker, M. I. Recht, A. A. S. Bhagat, F. E. Torres, A. G. Bell and R. H. Bruce, Lab Chip, 2011, 11, 3313
    DOI: 10.1039/C1LC20354A

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