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Issue 9, 2011
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Phaseguides: a paradigm shift in microfluidic priming and emptying

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Abstract

Phaseguide technology gives complete control over filling and emptying of any type of microfluidic structures, independent of the chamber and channel geometry. The technique is based on a step-wise advancement of the liquid–air interface using the meniscus pinning effect. In this paper, the main effects and parameters underlying the phaseguiding principle are discussed and a demonstration is given of its potential for dead angle filling, spatially controlled phaseguide overflow and sequential phaseguide overflow, all accumulating in a passive valving approach. Phaseguides represent a new direction in microfluidic design thinking that will prove a leap forward towards more simple, flexible and reliable microfluidic systems.

Graphical abstract: Phaseguides: a paradigm shift in microfluidic priming and emptying

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Article information


Submitted
29 Nov 2010
Accepted
16 Feb 2011
First published
10 Mar 2011

Lab Chip, 2011,11, 1596-1602
Article type
Paper

Phaseguides: a paradigm shift in microfluidic priming and emptying

P. Vulto, S. Podszun, P. Meyer, C. Hermann, A. Manz and G. A. Urban, Lab Chip, 2011, 11, 1596
DOI: 10.1039/C0LC00643B

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