Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 4, 2011
Previous Article Next Article

Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform

Author affiliations

Abstract

There is no technology available to support failing lung function for patients outside the hospital. An implantable lung assist device would augment lung function as a bridge to transplant or possible destination therapy. Utilizing biomimetic design principles, a microfluidic vascular network was developed for blood inflow from the pulmonary artery and blood return to the left atrium. Computational fluid dynamics analysis was used to optimize blood flow within the vascular network. A micro milled variable depth mold with 3D features was created to achieve both physiologic blood flow and shear stress. Gas exchange occurs across a thin silicone membrane between the vascular network and adjacent alveolar chamber with flowing oxygen. The device had a surface area of 23.1 cm2 and respiratory membrane thickness of 8.7 ± 1.2 μm. Carbon dioxide transfer within the device was 156 ml min−1m−2 and the oxygen transfer was 34 ml min−1m−2. A lung assist device based on tissue engineering architecture achieves gas exchange comparable to hollow fiber oxygenators yet does so while maintaining physiologic blood flow. This device may be scaled up to create an implantable ambulatory lung assist device.

Graphical abstract: Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Jul 2010, accepted on 15 Oct 2010 and first published on 13 Dec 2010


Article type: Paper
DOI: 10.1039/C0LC00158A
Citation: Lab Chip, 2011,11, 700-707

  •   Request permissions

    Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform

    D. M. Hoganson, H. I. Pryor II, E. K. Bassett, I. D. Spool and J. P. Vacanti, Lab Chip, 2011, 11, 700
    DOI: 10.1039/C0LC00158A

Search articles by author

Spotlight

Advertisements