Issue 12, 2011
From the journal:

Lab on a Chip

Versatile immunoassays based on isomagnetophoresis†

Young Ki Hahna  and  Je-Kyun Park*ab  

* Corresponding authors

a Department of Bio and Brain Engineering, College of Life Science and Bioengineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea
E-mail: jekyun@kaist.ac.kr
Fax: +82 42 350 4310
Tel: +82 42 350 4315

b KAIST Institute for the NanoCentury, 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea

Abstract

We report an isomagnetophoretic immunoassay capable of detecting an attomolar level of proteins and adjusting the dynamic range of target analytes. Here, the magnetic nanoparticles are used as labels on microbeads in sandwich-type immunoassay, detecting the amount of bound analytes by isomagnetophoretic focusing the solid-support microbeads under the magnetic susceptibility gradient and magnetic field in a microchannel. For the practical purpose, this platform was applied to detect three types of breast cancer biomarkers.

Graphical abstract: Versatile immunoassays based on isomagnetophoresis

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Article information

DOI
https://doi.org/10.1039/C0LC00569J
Article type
Communication
Submitted
06 Nov 2010
Accepted
26 Apr 2011
First published
13 May 2011

Lab Chip, 2011,11, 2045-2048

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Versatile immunoassays based on isomagnetophoresis

Y. K. Hahn and J. Park, Lab Chip, 2011, 11, 2045 DOI: 10.1039/C0LC00569J

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