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Issue 12, 2011
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Versatile immunoassays based on isomagnetophoresis

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Abstract

We report an isomagnetophoretic immunoassay capable of detecting an attomolar level of proteins and adjusting the dynamic range of target analytes. Here, the magnetic nanoparticles are used as labels on microbeads in sandwich-type immunoassay, detecting the amount of bound analytes by isomagnetophoretic focusing the solid-support microbeads under the magnetic susceptibility gradient and magnetic field in a microchannel. For the practical purpose, this platform was applied to detect three types of breast cancer biomarkers.

Graphical abstract: Versatile immunoassays based on isomagnetophoresis

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Publication details

The article was received on 06 Nov 2010, accepted on 26 Apr 2011 and first published on 13 May 2011


Article type: Communication
DOI: 10.1039/C0LC00569J
Citation: Lab Chip, 2011,11, 2045-2048
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    Versatile immunoassays based on isomagnetophoresis

    Y. K. Hahn and J. Park, Lab Chip, 2011, 11, 2045
    DOI: 10.1039/C0LC00569J

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