A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment†
Abstract
We present a new method to locally apply mechanical tensile and compressive force on single cells based on integration of a microfluidic device with an optical laser tweezers. This system can locate a single cell within customized wells exposing a square-like membrane segment to a functionalized bead. Beads are coated with extracellular