Issue 3, 2011
From the journal:

Lab on a Chip

Enzyme entrapped nanoporous scaffolds formed through flow-induced gelation in a microfluidic filter device for sensitive biosensing of organophosphorus compounds†

Donglai Lu,a   Guocheng Shao,b   Dan Du,ac   Jun Wang,a   Limin Wang,a   Wanjun Wangb  and  Yuehe Lin*a  

* Corresponding authors

a Pacific Northwest National Laboratory, Richland, WA, USA
E-mail: yuehe.lin@pnl.gov

b Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA, USA

c Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P.R. China

Abstract

A novel and versatile processing method was developed for the formation of gel scaffolds with in situAChE–AuNPs immobilization for biosensing of organophosphorus compounds. The biosensor designed by our new approach shows high sensitivity, selectivity and reactivation efficiency. This flow-induced immobilization technique opens up new pathways for designing a simple, fast, biocompatible, and cost-effective process for enhanced sensor performance and on-site monitoring of a variety of toxic organophosphorus compounds.

Graphical abstract: Enzyme entrapped nanoporous scaffolds formed through flow-induced gelation in a microfluidic filter device for sensitive biosensing of organophosphorus compounds

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Article information

DOI
https://doi.org/10.1039/C0LC00337A
Article type
Communication
Submitted
25 Aug 2010
Accepted
10 Nov 2010
First published
08 Dec 2010

Lab Chip, 2011,11, 381-384

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Enzyme entrapped nanoporous scaffolds formed through flow-induced gelation in a microfluidic filter device for sensitive biosensing of organophosphorus compounds

D. Lu, G. Shao, D. Du, J. Wang, L. Wang, W. Wang and Y. Lin, Lab Chip, 2011, 11, 381 DOI: 10.1039/C0LC00337A

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