Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 26, 2011
Previous Article Next Article

Highly stable, amphiphilic DNA-encoded nanoparticle conjugates for DNA encoding/decoding applications

Author affiliations

Abstract

We synthesized highly stable, amphiphilic polymer-protected DNA–Au nanoparticle conjugates (DNA–AuNPs) and developed a DNA encoding/decoding strategy using these particles. Here, DNA–AuNPs were encapsulated by amphiphilic poly(N-vinyl-2-pyrrolidone) (PVP) to make them more stable and soluble in both organic and aqueous solvents. These particles are stable in a wide range of salt concentrations, pH and temperatures and sustain their stability even after the addition of D,L-dithiothreitol. Finally, this polymer layer was readily removed and particle-modified DNA was decoded via the microarrayed chip and dark-field-based AuNP imaging technique.

Graphical abstract: Highly stable, amphiphilic DNA-encoded nanoparticle conjugates for DNA encoding/decoding applications

Back to tab navigation

Supplementary files

Article information


Submitted
17 Mar 2011
Accepted
10 May 2011
First published
02 Jun 2011

J. Mater. Chem., 2011,21, 9467-9470
Article type
Communication

Highly stable, amphiphilic DNA-encoded nanoparticle conjugates for DNA encoding/decoding applications

D. Lim, M. Cui and J. Nam, J. Mater. Chem., 2011, 21, 9467
DOI: 10.1039/C1JM11150G

Search articles by author

Spotlight

Advertisements