Jump to main content
Jump to site search

Issue 33, 2011
Previous Article Next Article

Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Author affiliations

Abstract

We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophagevia MR imaging.

Graphical abstract: Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Back to tab navigation

Publication details

The article was received on 21 Feb 2011, accepted on 06 Jun 2011 and first published on 21 Jul 2011


Article type: Paper
DOI: 10.1039/C1JM10764J
J. Mater. Chem., 2011,21, 12473-12478

  •   Request permissions

    Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

    E. Lim, E. Jang, B. Kim, J. Choi, K. Lee, J. Suh, Y. Huh and S. Haam, J. Mater. Chem., 2011, 21, 12473
    DOI: 10.1039/C1JM10764J

Search articles by author

Spotlight

Advertisements