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Issue 21, 2011
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Fluorescent magnetic nanoparticles for biomedical applications

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Abstract

The simultaneous combination of optical and magnetic resonance imaging (MRI) would greatly benefit in vivo disease diagnosis as well as in situ monitoring of living cells. In order to design dual detection of cells involving simultaneous imaging by fluorescent microscopy and MRI, nanoparticles with two reporters, a fluorescent dye and a superparamagnetic core, included in one particle were synthesized and characterized. The γ-Fe2O3 nanoparticles obtained by coprecipitation and oxidation were coated with silica (SiO2) or carboxymethyl chitosan (CMCS) and labeled with fluorescein isothiocyanate (FITC). The fluorescent label was covalently bound to the nanoparticles and was not quenched by the iron oxide core. The nanoparticles successfully labeled rat mesenchymal stem cells (rMSCs) in vitro. Relaxation time measurements found large amounts of iron inside the cells with FITC-labeled γ-Fe2O3SiO2-AP nanoparticles. Both MR and fluorescent imaging of a rat brain with implanted rMSCs labeled with FITC-labeled CMCS-modified silica-coated γ-Fe2O3 nanoparticles were performed.

Graphical abstract: Fluorescent magnetic nanoparticles for biomedical applications

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Publication details

The article was received on 11 Feb 2011, accepted on 21 Mar 2011 and first published on 18 Apr 2011


Article type: Paper
DOI: 10.1039/C1JM10621J
Citation: J. Mater. Chem., 2011,21, 7630-7639

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    Fluorescent magnetic nanoparticles for biomedical applications

    N. Chekina, D. Horák, P. Jendelová, M. Trchová, M. J. Beneš, M. Hrubý, V. Herynek, K. Turnovcová and E. Syková, J. Mater. Chem., 2011, 21, 7630
    DOI: 10.1039/C1JM10621J

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