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Issue 9, 2011
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Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands

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Abstract

Rattle-type magnetic mesoporous silica nanospheres (RMMSNs) with a magnetic core and a mesoporous silica shell were prepared, and then the surface properties of the nanospheres were modified with biocompatible polymer poly(ethylene glycol) (PEG) and cancer-cell-specific ligand folic acid (FA), with the aim of specifically targeting cancer cells. Combined Prussian blue staining, magnetic resonance imaging, and high-resolution sector field inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis revealed that the obtained RMMSN-PEG/FA nanocomposite can specifically target cancer cells over-expressing FA receptors (FRs). The nanocomposites displayed very low in vitro toxicity and negligible hemolytic activity, which is in favor of further biological applications. Water-insoluble anticancer drug docetaxel was loaded into the surface-modified RMMSNs and delivered into human cancer cellsviacell uptake. Surface conjugation with cancer-specific targeting agent FA increased the uptake into cancer cells that over-express FRs. In addition, after intravenous injection, the RMMSN-PEG/FA nanocomposite could be transported to the designated organs under an external magnetic field. Findings from this study suggest that the RMMSN-PEG/FA could be used as a platform for simultaneous imaging and therapeutic applications.

Graphical abstract: Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands

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Supplementary files

Article information


Submitted
30 Aug 2010
Accepted
04 Jan 2011
First published
19 Jan 2011

J. Mater. Chem., 2011,21, 3037-3045
Article type
Paper

Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands

H. Wu, G. Liu, S. Zhang, J. Shi, L. Zhang, Y. Chen, F. Chen and H. Chen, J. Mater. Chem., 2011, 21, 3037
DOI: 10.1039/C0JM02863K

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