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Issue 10, 2011
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Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity

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Abstract

A dual-targeting drug delivery and pH-sensitive controlled release system based on multi-functionalized graphene oxide (GO) was established in order to enhance the effect of targeted drug delivery and realize intelligently controlled release. A superparamagnetic GO–Fe3O4 nanohybrid was firstly prepared via a simple and effective chemical precipitation method. Then folic acid, a targeting agent toward some tumor cells, was conjugated onto Fe3O4 nanoparticlesvia the chemical linkage with amino groups of the 3-aminopropyl triethoxysilane (APS) modified superparamagnetic GO–Fe3O4 nanohybrid, to give the multi-functionalized GO. Doxorubicin hydrochloride (Dox) as an anti-tumor drug model was loaded onto the surface of this multi-functionalized GO via π–π stacking. The drug loading capacity of this multi-functionalized GO is as high as 0.387 mg mg−1 and the drug release depends strongly on pH values. Cell uptake studies were carried out using fluorescein isothiocyanate labeled or Dox loaded multi-functionalized GO to evaluate their targeted delivery property and toxicity to tumor cells. The results show that this multi-functionalized GO has potential applications for targeted delivery and the controlled release of anticancer drugs.

Graphical abstract: Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity

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Supplementary files

Article information


Submitted
01 Aug 2010
Accepted
28 Sep 2010
First published
19 Nov 2010

J. Mater. Chem., 2011,21, 3448-3454
Article type
Paper

Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity

X. Yang, Y. Wang, X. Huang, Y. Ma, Y. Huang, R. Yang, H. Duan and Y. Chen, J. Mater. Chem., 2011, 21, 3448
DOI: 10.1039/C0JM02494E

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