Cofactor        regeneration in polymersome nanoreactors: enzymatically catalysed Baeyer–Villiger reactions

Silvie A. Meeuwissen; Ana Rioz-Martínez; Gonzalo de Gonzalo; Marco W. Fraaije; Vicente Gotor; Jan C. M. van Hest

doi:10.1039/C1JM12407B

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Cofactor regeneration in polymersome nanoreactors: enzymatically catalysed Baeyer–Villiger reactions†

Silvie A. Meeuwissen,‡^a Ana Rioz-Martínez,‡^b Gonzalo de Gonzalo,^bc Marco W. Fraaije,^c Vicente Gotor^b and Jan C. M. van Hest*^a

Author affiliations

* Corresponding authors

^a Radboud University Nijmegen, Institute for Molecules and Materials, Department of Organic Chemistry, Heyendaalseweg 135, Nijmegen, The Netherlands
E-mail: j.vanhest@science.ru.nl
Fax: +31(0) 24 365 3393
Tel: +31(0) 24 365 2091

^b Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, c/Julián Clavería 8, Oviedo, Spain
E-mail: vgs@fq.uniovi.es
Fax: +34(0) 985 103448

^c Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
E-mail: m.w.fraaije@rug.nl
Fax: +31(0) 50 363 4165
Tel: +31(0) 50 363 4345

Abstract

Enzymatically catalysed Baeyer–Villiger reactions were successfully performed making use of our novel cofactor regenerating nanoreactors. The system is based on intrinsically porous polymeric vesicles loaded with enzymes that are able to regenerate the cofactor NADPH.

This article is part of the themed collection: Materials Chemistry in the Emerging Field of Synthetic Biology

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Article information

DOI: https://doi.org/10.1039/C1JM12407B
Article type: Communication
Submitted: 29 May 2011
Accepted: 23 Aug 2011
First published: 12 Sep 2011

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J. Mater. Chem., 2011,21, 18923-18926

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Cofactor regeneration in polymersome nanoreactors: enzymatically catalysed Baeyer–Villiger reactions

S. A. Meeuwissen, A. Rioz-Martínez, G. de Gonzalo, M. W. Fraaije, V. Gotor and J. C. M. van Hest, J. Mater. Chem., 2011, 21, 18923 DOI: 10.1039/C1JM12407B

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Journal of Materials Chemistry