Issue 25, 2011
From the journal:

Journal of Materials Chemistry

Self-assembly of calcium phosphatenanoparticles into hollow spheres induced by dissolved amino acids

Daniel Hagmeyer,a   Kathirvel Ganesan,a   Johannes Ruesing,a   Daniel Schunk,b   Christian Mayer,b   Archan Dey,c   Nico A. J. M. Sommerdijkc  and  Matthias Epple*a  

* Corresponding authors

a Institute of Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstrasse 5-7, Essen, Germany
E-mail: matthias.epple@uni-due.de

b Institute of Physical Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstrasse 5-7, Essen, Germany

c Eindhoven University of Technology, Chemical Engineering and Chemistry, Materials and Interface Chemistry, Eindhoven, The Netherlands

Abstract

Nanoparticles of calcium phosphate assemble spontaneously within a few seconds into hollow spheres with a diameter around 200–300 nm in the presence of dissolved amino acids and dipeptides. The process of formation was followed by cryo-transmission electron microscopy (cryoTEM), proving their hollow nature which was also confirmed by nano-indentation by atomic force microscopy (AFM). The hollow spheres were analyzed by scanning electron microscopy (SEM), dynamic light scattering (DLS), nanoparticle tracking analysis (NTA) and elemental analysis. The hollow spheres were moderately stable against heating and ultrasonication. A self-assembly of the primarily formed calcium phosphate nanoparticles around amino acid-rich domains in water is proposed. As this process was observed with different amino acids, it appears to be a more general phenomenon.

Graphical abstract: Self-assembly of calcium phosphate nanoparticles into hollow spheres induced by dissolved amino acids

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Article information

DOI
https://doi.org/10.1039/C1JM11316J
Article type
Paper
Submitted
28 Mar 2011
Accepted
26 Apr 2011
First published
26 May 2011

J. Mater. Chem., 2011,21, 9219-9223

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Self-assembly of calcium phosphate nanoparticles into hollow spheres induced by dissolved amino acids

D. Hagmeyer, K. Ganesan, J. Ruesing, D. Schunk, C. Mayer, A. Dey, N. A. J. M. Sommerdijk and M. Epple, J. Mater. Chem., 2011, 21, 9219 DOI: 10.1039/C1JM11316J

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