Issue 22, 2011

Silica-based complex nanorattles as multifunctional carrier for anticancer drug

Abstract

In this work, we demonstrate a new route to generate silica-based multifunctional complex nanorattles. By using SnO2 hollow nanospheres as the starting template, we are able to build a new type of rattle-in-ball hollow structure with multi-level interior architecture, where the core of a nanorattle is itself another smaller rattle. Moreover, additional functionality can be introduced by forming Au nanoparticles in the interstitial space. Such unique hollow nanostructures are believed to be very useful as nanoreactors for selective catalysis. Magnetic functionality can also be incorporated by using an α-Fe2O3 nanospindle as the starting template followed by in situreduction to Fe3O4. This type of ellipsoidal nanorattle is feasible for drug delivery as it is shown to be highly biocompatible and non-cytotoxic. The cell viability assay proves that the sample is an efficient drug delivery vehicle exhibiting similar anticancer efficacy against MCF-7 carcinoma cells as compared to the free DOX. By constructing these two types of complex nanorattles as examples, we demonstrate new possible routes to generate versatile hollow nanostructures with distinct architectures and chemical compositions, thus widening their application potential.

Graphical abstract: Silica-based complex nanorattles as multifunctional carrier for anticancer drug

Supplementary files

Article information

Article type
Paper
Submitted
11 Mar 2011
Accepted
08 Apr 2011
First published
26 Apr 2011

J. Mater. Chem., 2011,21, 8052-8056

Silica-based complex nanorattles as multifunctional carrier for anticancer drug

Y. Hu, X. T. Zheng, J. S. Chen, M. Zhou, C. M. Li and X. W. (. Lou, J. Mater. Chem., 2011, 21, 8052 DOI: 10.1039/C1JM11060H

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