Jump to main content
Jump to site search

Issue 7, 2011
Previous Article Next Article

NMR analysis of chiral alcohols and amines: development of an environmentally benign “in tube” procedure with high efficiency and improved detection limit

Author affiliations

Abstract

A fast and efficient approach was developed for the NMR analysis of chiral alcohols and amines using readily available enantiopure MPA (α-methoxy-α-phenylacetic acid) and MTPA (α-methoxy-α-trifluoromethylphenylacetic acid) as chiral derivatizing agents. The procedure requires less than 5 min (including sample preparation time) for analysis using routine NMR hardware and allows accurate measurements for <0.01 mg of the sample of chiral compounds. Direct “in tube” analysis can be performed with high efficiency to determine enantiomeric purity and absolute configuration, as well as to monitor reactions in asymmetric synthesis and catalysis. The developed procedure is superior in terms of waste-free analysis of chiral compounds for environmentally benign applications.

Graphical abstract: NMR analysis of chiral alcohols and amines: development of an environmentally benign “in tube” procedure with high efficiency and improved detection limit

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Feb 2011, accepted on 13 Apr 2011 and first published on 09 Jun 2011


Article type: Paper
DOI: 10.1039/C1GC15191F
Citation: Green Chem., 2011,13, 1735-1744
  •   Request permissions

    NMR analysis of chiral alcohols and amines: development of an environmentally benign “in tube” procedure with high efficiency and improved detection limit

    N. V. Orlov and V. P. Ananikov, Green Chem., 2011, 13, 1735
    DOI: 10.1039/C1GC15191F

Search articles by author

Spotlight

Advertisements