Issue 5, 2011
From the journal:

Green Chemistry

Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing†

Malte Brasholz,*a   Karin von Känel,a   Christian H. Hornung,a   Simon Sauberna  and  John Tsanaktsidis*a  

* Corresponding authors

a CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, Australia
E-mail: john.tsanaktsidis@csiro.au
Tel: +61 3 9545 2222

Abstract

Using a continuous flow reactor, the dehydration of D-fructose and other carbohydrates to 5-(chloromethyl)furfural (1) is achieved in reaction times as short as 60 s. The biphasic flow process allows for high-yielding multigram scale production of CMF (1) which is obtained with excellent purity after a simple extractive work-up. Efficient conversion of D-fructose into 5-(hydroxymethyl)furfural (2) and levulinic acid (6) is also demonstrated using flow reactor techniques.

Graphical abstract: Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing

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Article information

DOI
https://doi.org/10.1039/C1GC15107J
Article type
Communication
Submitted
27 Jan 2011
Accepted
17 Feb 2011
First published
11 Mar 2011

Green Chem., 2011,13, 1114-1117

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Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing

M. Brasholz, K. von Känel, C. H. Hornung, S. Saubern and J. Tsanaktsidis, Green Chem., 2011, 13, 1114 DOI: 10.1039/C1GC15107J

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