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Issue 11, 2011
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Synthesis of ranitidine (Zantac) from cellulose-derived 5-(chloromethyl)furfural

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Abstract

The biomass-derived platform chemical 5-(chloromethyl)furfural is converted into the blockbuster antiulcer drug ranitidine (Zantac) in four steps with an overall 68% isolated yield.

Graphical abstract: Synthesis of ranitidine (Zantac) from cellulose-derived 5-(chloromethyl)furfural

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Article information


Submitted
11 May 2011
Accepted
29 Aug 2011
First published
19 Sep 2011

Green Chem., 2011,13, 3101-3102
Article type
Communication

Synthesis of ranitidine (Zantac) from cellulose-derived 5-(chloromethyl)furfural

M. Mascal and S. Dutta, Green Chem., 2011, 13, 3101
DOI: 10.1039/C1GC15537G

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