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Issue 4, 2011
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Greener solvents for ruthenium and palladium-catalysed aromatic C–H bond functionalisation

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Abstract

The formation of carbon-carbon bonds by transition metal-catalysed direct functionalisation of C–H bonds has recently emerged as a greener alternative to traditional cross-coupling reactions. Despite tremendous improvement of the catalytic efficiency allowing reactions under milder conditions or lower catalyst loadings, this type of transformation still suffers from a major limitation with regards to green chemistry concerning the reaction media since the preferred solvents for these transformations are the undesirable and toxic, high boiling point, polar, aprotic, N-methylpyrrolidinone (NMP), dimethylformamide (DMF) or dimethylacetamide (DMAc). Recently, efforts have been made to perform these reactions in greener or more environmentally acceptable media. This review summarises the contributions made in this direction during the past few years.

Graphical abstract: Greener solvents for ruthenium and palladium-catalysed aromatic C–H bond functionalisation

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Article information


Submitted
06 Dec 2010
Accepted
07 Jan 2011
First published
09 Feb 2011

Green Chem., 2011,13, 741-753
Article type
Critical Review

Greener solvents for ruthenium and palladium-catalysed aromatic C–H bond functionalisation

C. Fischmeister and H. Doucet, Green Chem., 2011, 13, 741
DOI: 10.1039/C0GC00885K

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