Issue 3, 2011
From the journal:

Green Chemistry

Water-prompted synthesis of alkyl nitrile derivatives viaKnoevenagel condensation and Michael addition reaction†

Ebrahim Soleimani,*a   Mohammad Mehdi Khodaei,*a   Nasim Batooiea  and  Mostafa Baghbanzadehb  

* Corresponding authors

a Department of Chemistry, Razi University, Kermanshah, Iran
E-mail: e_soleimanirazi@yahoo.com

b Department of Chemistry, Christian Doppler Laboratory for Microwave Chemistry, Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, Graz, Austria

Abstract

A straightforward and efficient method for the synthesis of nitriles or β-cyanocarbonyls via Knoevenagel condensation and Michael addition reaction of a barbituric acid, aldehyde and sodium cyanide in water without using any catalyst or activation at 70 °C is reported.

Graphical abstract: Water-prompted synthesis of alkyl nitrile derivatives via Knoevenagel condensation and Michael addition reaction

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Article information

DOI
https://doi.org/10.1039/C0GC00739K
Article type
Communication
Submitted
27 Oct 2010
Accepted
07 Jan 2011
First published
25 Jan 2011

Green Chem., 2011,13, 566-569

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Water-prompted synthesis of alkyl nitrile derivatives via Knoevenagel condensation and Michael addition reaction

E. Soleimani, M. M. Khodaei, N. Batooie and M. Baghbanzadeh, Green Chem., 2011, 13, 566 DOI: 10.1039/C0GC00739K

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