Issue 2, 2011
From the journal:

Green Chemistry

An eco-sustainable erbium(iii)-catalyzed method for formation/cleavage of O-tert-butoxy carbonates†

Antonio Procopio,*a   Giancarlo Cravotto,b   Manuela Oliverio,a   Paola Costanzo,a   Monica Nardic  and  Rosina Paonessaa  

* Corresponding authors

a Dipartimento Farmaco-Biologico, Università degli Studi della Magna Græcia Complesso Ninì Barbieri, Roccelletta di Borgia, (CZ), Italy
E-mail: procopio@unicz.it
Fax: +39 0961 369 5713
Tel: +39 0961 369 4120

b Dipartimento di Scienza e Tecnologia del Farmaco Università di Torino Via Giuria 9, Torino, (Italy)

c Dipartimento di Chimica, Università della Calabria, Ponte Bucci, Arcavacata di Rende, (CS), Italy

Abstract

A new simple and effective method for the formation/cleavage of O-tert-butoxy carbonates of alcohols and phenols is proposed. Mesoporous silica-supported Er(III) (ErIII-MCM-41) was used as an efficient and reusable solid catalyst in the solvent-free ultrasound-assisted synthesis of Boc-carbonate derivatives of a wide range of alcohols and phenols. The fast, selective deprotection of Boc-derivatives is achieved with a very low amount of Er(OTf)3 in ethanol under microwave irradiation. Therefore, the entire protection/de-protection process is very attractive, from the point of view of sustainability.

Graphical abstract: An eco-sustainable erbium(iii)-catalyzed method for formation/cleavage of O-tert-butoxy carbonates

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Article information

DOI
https://doi.org/10.1039/C0GC00728E
Article type
Paper
Submitted
25 Oct 2010
Accepted
02 Dec 2010
First published
11 Jan 2011

Green Chem., 2011,13, 436-443

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An eco-sustainable erbium(III)-catalyzed method for formation/cleavage of O-tert-butoxy carbonates

A. Procopio, G. Cravotto, M. Oliverio, P. Costanzo, M. Nardi and R. Paonessa, Green Chem., 2011, 13, 436 DOI: 10.1039/C0GC00728E

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