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Volume 150, 2011
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Potential for the detection of molecular complexes and determination of interaction geometry by 2DIR: Application to protein sciences

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Abstract

The ability to detect molecular complexes and determine their geometries is crucial to our understanding of all biological phenomena, including protein structures and functions. We recently demonstrated that a novel 2DIR technique, EVV 2DIR spectroscopy, can be used for this purpose. In this paper, we evaluate the potential utility of the method for the analysis of protein composition, structure and function. In order to do this we apply computational tools to a group of selected biological systems, for which our calculated spectra all showed features that can in principle be detected with existing sensitivities. We also investigate the possibility of using our technique to detect and analyse hydrogen-bonded systems through a tyrosine–water model.

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Publication details

The article was received on 13 Jan 2011, accepted on 17 Feb 2011 and first published on 09 May 2011


Article type: Paper
DOI: 10.1039/C1FD00007A
Citation: Faraday Discuss., 2011,150, 161-174
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    Potential for the detection of molecular complexes and determination of interaction geometry by 2DIR: Application to protein sciences

    R. Guo, M. Miele, E. M. Gardner, F. Fournier, K. M. Kornau, I. R. Gould and D. R. Klug, Faraday Discuss., 2011, 150, 161
    DOI: 10.1039/C1FD00007A

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