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Issue 32, 2011
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Cytotoxic gold(I)-bearing dendrimers from alkyne precursors

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Abstract

A series of four dendrimers end-functionalized with gold(I) has been prepared from alkyne-terminated precursors and (tricyclohexylphosphine)gold(I) azide. Isolated yields range from 84–89%, based on gold. The first-generation dendrimer is cytotoxic toward 3T3 mouse fibroblast cells. Apoptosis ensues within 6 h of treatment with gold(I).

Graphical abstract: Cytotoxic gold(i)-bearing dendrimers from alkyne precursors

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Publication details

The article was received on 04 Apr 2011, accepted on 22 Jun 2011 and first published on 15 Jul 2011


Article type: Communication
DOI: 10.1039/C1DT10578G
Citation: Dalton Trans., 2011,40, 8083-8085
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    Cytotoxic gold(I)-bearing dendrimers from alkyne precursors

    T. J. Robilotto, D. S. Alt, H. A. von Recum and T. G. Gray, Dalton Trans., 2011, 40, 8083
    DOI: 10.1039/C1DT10578G

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