Issue 32, 2011
From the journal:

Dalton Transactions

Cytotoxic gold(i)-bearing dendrimers from alkyne precursors†

Thomas J. Robilotto,a   Daniel S. Alt,b   Horst A. von Recum*b  and  Thomas G. Gray*a  

* Corresponding authors

a Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, USA
E-mail: tgray@case.edu
Fax: (216)368-3006
Tel: (216) 368-0991

b Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, USA
E-mail: hav1@case.edu
Fax: (216)368-4969
Tel: (216) 368-5513

Abstract

A series of four dendrimers end-functionalized with gold(I) has been prepared from alkyne-terminated precursors and (tricyclohexylphosphine)gold(I) azide. Isolated yields range from 84–89%, based on gold. The first-generation dendrimer is cytotoxic toward 3T3 mouse fibroblast cells. Apoptosis ensues within 6 h of treatment with gold(I).

Graphical abstract: Cytotoxic gold(i)-bearing dendrimers from alkyne precursors

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Article information

DOI
https://doi.org/10.1039/C1DT10578G
Article type
Communication
Submitted
04 Apr 2011
Accepted
22 Jun 2011
First published
15 Jul 2011

Dalton Trans., 2011,40, 8083-8085

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Cytotoxic gold(I)-bearing dendrimers from alkyne precursors

T. J. Robilotto, D. S. Alt, H. A. von Recum and T. G. Gray, Dalton Trans., 2011, 40, 8083 DOI: 10.1039/C1DT10578G

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