[Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule

Sian H. Crook; Brian E. Mann; Anthony J. H. M. Meijer; Harry Adams; Philip Sawle; David Scapens; Roberto Motterlini

doi:10.1039/C1DT10125K

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[Mn(CO)₄{S₂CNMe(CH₂CO₂H)}], a new water-soluble CO-releasing molecule†

Sian H. Crook,^a Brian E. Mann,^a Anthony J. H. M. Meijer,^a Harry Adams,^a Philip Sawle,^b David Scapens^a and Roberto Motterlini^c

Author affiliations

^a Department of Chemistry, University of Sheffield, Sheffield, United Kingdom
E-mail: b.mann@sheffield.ac.uk
Fax: 0044 (0)114 2738673
Tel: 0044 (0)114 2229332

^b Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom

^c Department of Drug Discovery and Development, Italian Institute of Technology, Via Morego, 30, Genova, ITALY
E-mail: roberto.motterlini@iit.it
Fax: +39-01072032
Tel: +39-01071781547

Abstract

[Mn(CO)₄{S₂CNMe(CH₂CO₂H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of CO results in a relatively stable solution of the compound, while in the presence of a CO receptor or a ligand to prevent the rebinding of CO, the CO is lost rapidly. The X-ray structure was determined.

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Article information

DOI: https://doi.org/10.1039/C1DT10125K
Article type: Paper
Submitted: 21 Jan 2011
Accepted: 02 Feb 2011
First published: 14 Mar 2011

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Dalton Trans., 2011,40, 4230-4235

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[Mn(CO)₄{S₂CNMe(CH₂CO₂H)}], a new water-soluble CO-releasing molecule

S. H. Crook, B. E. Mann, A. J. H. M. Meijer, H. Adams, P. Sawle, D. Scapens and R. Motterlini, Dalton Trans., 2011, 40, 4230 DOI: 10.1039/C1DT10125K

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Dalton Transactions