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Issue 13, 2011
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Suzuki–Miyaura cross-coupling coupling reactions with low catalyst loading: a green and sustainable protocol in pure water

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Abstract

The Suzuki–Miyaura coupling reaction represents one of the most important synthetic transformations developed in the 20th century. However, the use of toxic organic solvents remains a scientific challenge and an aspect of economical and ecological relevance, and benign water as a reaction medium was found to be highly effective to overcome some of these issues. In the present manuscript, we described Suzuki–Miyaura coupling reactions in neat water, without using any phase transfer reagent. Notably, this protocol also works with ultra-low loading of catalyst with high turnover numbers and also able to couple challenging substrates like aryl chlorides.

Graphical abstract: Suzuki–Miyaura cross-coupling coupling reactions with low catalyst loading: a green and sustainable protocol in pure water

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Publication details

The article was received on 25 Nov 2010, accepted on 31 Jan 2011 and first published on 22 Feb 2011


Article type: Communication
DOI: 10.1039/C0DT01637C
Citation: Dalton Trans., 2011,40, 3116-3121
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    Suzuki–Miyaura cross-coupling coupling reactions with low catalyst loading: a green and sustainable protocol in pure water

    A. Fihri, D. Luart, C. Len, A. Solhy, C. Chevrin and V. Polshettiwar, Dalton Trans., 2011, 40, 3116
    DOI: 10.1039/C0DT01637C

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