Issue 5, 2011
From the journal:

Dalton Transactions

Antiproliferative activity of chelating N,O- and N,N-ruthenium(ii) arene functionalised poly(propyleneimine) dendrimer scaffolds†

Preshendren Govender,a   Anna K. Renfrew,b   Catherine M. Clavel,b   Paul J. Dyson,b   Bruno Therrienc  and  Gregory S. Smith*a  

* Corresponding authors

a Department of Chemistry, University of Cape Town, Rondebosch, Cape Town, South Africa
E-mail: Gregory.Smith@uct.ac.za
Fax: +27-21-6505195

b Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

c Institute of Chemistry, University of Neuchatel, 51 Ave de Bellevaux, Neuchatel, Switzerland

Abstract

Chelating neutral (N,O) and cationic (N,N) first- and second-generation ruthenium(II) arene metallodendrimers based on poly(propyleneimine) dendrimer scaffolds were obtained from dinuclear arene ruthenium precursors by reactions with salicylaldimine and iminopyridyl dendritic ligands, respectively. The N,N cationic complexes were isolated as hexafluorophosphate salts and were characterised by NMR and IR spectroscopy, and MALDI-TOF mass spectrometry. Related mononuclear complexes were obtained in a similar manner and their molecular structures have been determined by X-ray diffraction analysis. The cytotoxicities of the mono- and multinuclear complexes were established using A2780 and A2780cisR human ovarian carcinoma cancer cell lines.

Graphical abstract: Antiproliferative activity of chelating N,O- and N,N-ruthenium(ii) arene functionalised poly(propyleneimine) dendrimer scaffolds

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0DT00761G
Article type
Paper
Submitted
30 Jun 2010
Accepted
18 Nov 2010
First published
17 Dec 2010

Dalton Trans., 2011,40, 1158-1167

Permissions

Request permissions

Antiproliferative activity of chelating N,O- and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds

P. Govender, A. K. Renfrew, C. M. Clavel, P. J. Dyson, B. Therrien and G. S. Smith, Dalton Trans., 2011, 40, 1158 DOI: 10.1039/C0DT00761G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements