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Issue 7, 2011
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Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

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Abstract

A highly practical, catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents, which were prepared in situ from commercially available Grignard reagents or arylboronic acids, was developed. A chiral phosphoramide ligand was essential for promoting the addition reactions in high yields with high enantioselectivities.

Graphical abstract: Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

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Publication details

The article was received on 28 Mar 2011, accepted on 02 Jun 2011 and first published on 01 Jul 2011


Article type: Paper
DOI: 10.1039/C1CY00108F
Catal. Sci. Technol., 2011,1, 1149-1158

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    Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

    M. Hatano, R. Gouzu, T. Mizuno, H. Abe, T. Yamada and K. Ishihara, Catal. Sci. Technol., 2011, 1, 1149
    DOI: 10.1039/C1CY00108F

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