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Issue 7, 2011
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Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkylGrignard reagents or arylboronic acids

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Abstract

A highly practical, catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents, which were prepared in situ from commercially available Grignard reagents or arylboronic acids, was developed. A chiral phosphoramide ligand was essential for promoting the addition reactions in high yields with high enantioselectivities.

Graphical abstract: Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

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Supplementary files

Article information


Submitted
28 Mar 2011
Accepted
02 Jun 2011
First published
01 Jul 2011

Catal. Sci. Technol., 2011,1, 1149-1158
Article type
Paper

Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

M. Hatano, R. Gouzu, T. Mizuno, H. Abe, T. Yamada and K. Ishihara, Catal. Sci. Technol., 2011, 1, 1149 DOI: 10.1039/C1CY00108F

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