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Issue 1, 2012
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The fluorous effect in biomolecular applications

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From being a niche area only a few decades ago, fluorous chemistry has gained momentum and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous applicative innovations that stretch among different fields: from catalysis to separation science, from supramolecular to materials and analytical chemistry. Recently, the unique features of perfluorinated compounds have reached the attention of the biochemists' audience. This tutorial review introduces the basic concepts of fluorous chemistry and illustrates its main biomolecular applications. Special attention has been given to fluorous microarrays and their combination with Mass-Spectroscopy (MS) techniques, to protein properties modification by the introduction of local fluorous domains, and to the most recent applications of 19F-Magnetic Resonance Imaging (19F-MRI).

Graphical abstract: The fluorous effect in biomolecular applications

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Article information

30 Mar 2011
First published
20 Jun 2011

Chem. Soc. Rev., 2012,41, 31-42
Article type
Tutorial Review

The fluorous effect in biomolecular applications

M. Cametti, B. Crousse, P. Metrangolo, R. Milani and G. Resnati, Chem. Soc. Rev., 2012, 41, 31
DOI: 10.1039/C1CS15084G

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