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Issue 4, 2011
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C–H functionalization logic in total synthesis

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In this critical review, the strategic and economic benefits of C–H functionalization logic will be analyzed through the critical lens of total synthesis. In order to illustrate the dramatically simplifying effects this type of logic can potentially have on synthetic planning, we take the reader through a series of case studies in which it has already been successfully applied. In the first section, a chronological look at key historical syntheses will be examined, leading into modern day examples. In the second section, our own experience with applying and executing synthesis with a C–H functionalization “mindset” will be discussed (114 references).

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The article was received on 15 Nov 2010 and first published on 07 Feb 2011

Article type: Critical Review
DOI: 10.1039/C0CS00182A
Chem. Soc. Rev., 2011,40, 1976-1991

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    C–H functionalization logic in total synthesis

    W. R. Gutekunst and P. S. Baran, Chem. Soc. Rev., 2011, 40, 1976
    DOI: 10.1039/C0CS00182A

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