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Issue 8, 2011
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Azobenzene photoswitches for biomolecules

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The photoisomerization of azobenzene has been known for almost 75 years but only recently has this process been widely applied to biological systems. The central challenge of how to productively couple the isomerization process to a large functional change in a biomolecule has been met in a number of instances and it appears that effective photocontrol of a large variety of biomolecules may be possible. This critical review summarizes key properties of azobenzene that enable its use as a photoswitch in biological systems and describes strategies for using azobenzene photoswitches to drive functional changes in peptides, proteins, nucleic acids, lipids, and carbohydrates (192 references).

Graphical abstract: Azobenzene photoswitches for biomolecules

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Publication details

The article was received on 22 Jan 2011 and first published on 12 Apr 2011

Article type: Critical Review
DOI: 10.1039/C1CS15023E
Citation: Chem. Soc. Rev., 2011,40, 4422-4437

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    Azobenzene photoswitches for biomolecules

    A. A. Beharry and G. A. Woolley, Chem. Soc. Rev., 2011, 40, 4422
    DOI: 10.1039/C1CS15023E

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