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Issue 3, 2011
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Purine 5′,8-cyclonucleoside lesions: chemistry and biology

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Abstract

5′,8-Cyclo-2′-deoxyadenosine and 5′,8-cyclo-2′-deoxyguanosine in their 5′R and 5′S diastereomeric forms are tandem-type lesions observed among the DNA modifications and identified in mammalian cellular DNAin vivo. These lesions result from the chemistry of the C5′ radicals generated by the attack of HO˙ radicals to 2-deoxyribose units. Quantitative determination of these lesions in biological samples as biomarkers of free radical damage is a challenge. Results reported for irradiated samples of calf thymus DNA have been critically reviewed, underlining the need of further research for the potential involvement of these lesions in human health (76 references).

Graphical abstract: Purine 5′,8-cyclonucleoside lesions: chemistry and biology

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Article information


Submitted
02 Aug 2010
First published
11 Jan 2011

Chem. Soc. Rev., 2011,40, 1368-1382
Article type
Critical Review

Purine 5′,8-cyclonucleoside lesions: chemistry and biology

C. Chatgilialoglu, C. Ferreri and M. A. Terzidis, Chem. Soc. Rev., 2011, 40, 1368
DOI: 10.1039/C0CS00061B

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