Metal-ion induced transition from multi- to single-bilayer tubes in histidine bearing lipids and formation of monodisperse Au nanoparticles

Abstract

We report that a histidine based cationic lipid forms multi-bilayer nanotubes and the addition of metal ions such as Cu²⁺ and Au³⁺ induces transformation into single-bilayer nanotubes owing to coordination of the metal ions on the nanotube surface. The morphological transition was detected with X-ray scattering and electron microscopy. IR showed that the metal coordination is presumably the major driving force. The reduction of Au³⁺ ions on the tube surface produced gold nanoparticles attached on the nanotube surface. The nanoparticle was almost monodisperse with the average diameter of 1.7 nm and the standard deviation σ of 0.29, which is remarkably narrower than that of previously reported lipid systems. The obtained particles were stable and no further aggregation and growth was observed after one week, providing a powerful and facile tool for producing nanoparticles in a wide range of applications.