Issue 23, 2011
From the journal:

Physical Chemistry Chemical Physics

Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA†

Arnošt Mládek,a   Jiří Šponer,a   Bobby G. Sumpter,b   Miguel Fuentes-Cabrera*b  and  Judit E. Šponer*a  

* Corresponding authors

a Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, Brno, Czech Republic
E-mail: judit@ncbr.chemi.muni.cz

b Center for Nanophase Materials Sciences, and Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, P. O. Box 2008, Oak Ridge, USA
E-mail: fuentescabma@ornl.gov

Abstract

Quantum chemical calculations reveal that neither steric hindrance nor less polar solvent medium is able to reduce the otherwise high hydrolysis rate of arsenate-esters. These results question the stability of As-DNA not only in aqueous but also in non-aqueous environments.

Graphical abstract: Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CP20423H
Article type
Communication
Submitted
17 Feb 2011
Accepted
13 Apr 2011
First published
11 May 2011

Phys. Chem. Chem. Phys., 2011,13, 10869-10871

Permissions

Request permissions

Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA

A. Mládek, J. Šponer, B. G. Sumpter, M. Fuentes-Cabrera and J. E. Šponer, Phys. Chem. Chem. Phys., 2011, 13, 10869 DOI: 10.1039/C1CP20423H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements