Issue 6, 2011
From the journal:

CrystEngComm

Fifty-year old samples of progesterone demonstrate the complex role of synthetic impurities in stabilizing a metastable polymorph†

Robert W. Lancaster,*a   Lisa D. Harrisa  and  David Pearson‡b  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon St, London, UK
E-mail: r.lancaster@ucl.ac.uk
Fax: +44 (0)20 7679 7463
Tel: +44 (0)20 7679 4665

b Pharmorphix Limited, 250 Cambridge Science Park, Milton Road, Cambridge, UK

Abstract

We describe a unique experiment whereby analysis of fifty-year old samples of progesterone shows that a metastable, ‘disappearing’ polymorph contains several impurities that are not found in the stable form.

Graphical abstract: Fifty-year old samples of progesterone demonstrate the complex role of synthetic impurities in stabilizing a metastable polymorph

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Article information

DOI
https://doi.org/10.1039/C0CE00858C
Article type
Communication
Submitted
16 Nov 2010
Accepted
16 Dec 2010
First published
28 Jan 2011

CrystEngComm, 2011,13, 1775-1777

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Fifty-year old samples of progesterone demonstrate the complex role of synthetic impurities in stabilizing a metastable polymorph

R. W. Lancaster, L. D. Harris and D. Pearson, CrystEngComm, 2011, 13, 1775 DOI: 10.1039/C0CE00858C

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