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Issue 46, 2011
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Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly

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Abstract

A series of heptapeptides comprising the core sequence Aβ(16–20), KLVFF, of the amyloid β peptide coupled with paired N-terminal γ-amino acids are investigated in terms of cytotoxicity reduction and binding to the full Aβ peptide, both pointing to inhibition of fibrillisation for selected compounds. This is related to the self-assembly capacity of the heptapeptides.

Graphical abstract: Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly

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Publication details

The article was received on 05 Sep 2011, accepted on 19 Oct 2011 and first published on 31 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC15493A
Citation: Chem. Commun., 2011,47, 12470-12472

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    Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly

    V. Castelletto, G. Cheng and I. W. Hamley, Chem. Commun., 2011, 47, 12470
    DOI: 10.1039/C1CC15493A

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