Issue 37, 2011
From the journal:

Chemical Communications

A phosphoarginine containing peptide as an artificial SH2 ligand†

Frank T. Hofmann,a   Claudia Lindemann,a   Helen Salia,a   Philipp Adamitzki,a   John Karanicolasb  and  Florian P. Seebeck*ac  

* Corresponding authors

a Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, Dortmund, Germany

b Center for Bioinformatics and Department of Molecular Biosciences, The University of Kansas, 2030 Becker Drive, Lawrence, USA

c Department of Chemistry, University of Basel, St. Johanns-Ring 19, Basel, Switzerland
E-mail: florian.seebeck@unibas.ch

Abstract

We have developed a synthesis of phosphoarginine containing peptides using a bis(2,2,2-trichloroethyl) protected phosphoarginine derivative as building block. Binding studies and computer modelling demonstrate the ability of the SH2 domain from Src kinase to recognize a phosphoarginine-containing peptide in a phosphoryl group-dependent manner.

Graphical abstract: A phosphoarginine containing peptide as an artificial SH2 ligand

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Article information

DOI
https://doi.org/10.1039/C1CC13341A
Article type
Communication
Submitted
05 Jun 2011
Accepted
03 Aug 2011
First published
19 Aug 2011

Chem. Commun., 2011,47, 10335-10337

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A phosphoarginine containing peptide as an artificial SH2 ligand

F. T. Hofmann, C. Lindemann, H. Salia, P. Adamitzki, J. Karanicolas and F. P. Seebeck, Chem. Commun., 2011, 47, 10335 DOI: 10.1039/C1CC13341A

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