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Issue 35, 2011
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Synthesis of a MUC1-glycopeptide–BSA conjugate vaccine bearing the 3′-deoxy-3′-fluoro-Thomsen–Friedenreich antigen

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Abstract

A novel MUC1-glycopeptide–BSA conjugate vaccine with a specifically fluorinated Thomsen–Friedenreich antigen side chain at Thr6 was prepared. Preliminary immunological experiments reveal specific binding of the tumor-associated glycopeptide antigen analog by anti-MUC1-mouse antibodies.

Graphical abstract: Synthesis of a MUC1-glycopeptide–BSA conjugate vaccine bearing the 3′-deoxy-3′-fluoro-Thomsen–Friedenreich antigen

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Publication details

The article was received on 30 May 2011, accepted on 19 Jul 2011 and first published on 04 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC13184B
Chem. Commun., 2011,47, 9903-9905

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    Synthesis of a MUC1-glycopeptide–BSA conjugate vaccine bearing the 3′-deoxy-3′-fluoro-Thomsen–Friedenreich antigen

    A. Hoffmann-Röder and M. Johannes, Chem. Commun., 2011, 47, 9903
    DOI: 10.1039/C1CC13184B

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