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Issue 24, 2011
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Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones

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Abstract

Up to now, the synthesis of quinazolinones has required lengthy synthetic procedures. Here, we describe an innovative one-pot multicomponent reaction leading to highly substituted quinazolinones. We believe that this novel transformation may open the door for the generation of new and pharmacologically active quinazolinones, but, most important of all, the resurrection of the imide-Ugi scaffold paves the way for the synthesis of novel molecular architectures

Graphical abstract: Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones

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Publication details

The article was received on 11 Apr 2011, accepted on 28 Apr 2011 and first published on 17 May 2011


Article type: Communication
DOI: 10.1039/C1CC12067K
Citation: Chem. Commun., 2011,47, 6966-6968
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    Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones

    R. Mossetti, T. Pirali, D. Saggiorato and G. C. Tron, Chem. Commun., 2011, 47, 6966
    DOI: 10.1039/C1CC12067K

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