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Issue 26, 2011
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A luminescent oxygen channeling biosensor that measures small GTPase activation

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Abstract

We established a homogeneous luminescent oxygen channeling sensor for measuring activation states of small GTPases. The assay quantifies activated GTPases in cell lysates, can be applied to different GTPases, and can be used for multiplex screening. The study will provide guidelines for determining activation states of diverse GTPases in various biological contexts.

Graphical abstract: A luminescent oxygen channeling biosensor that measures small GTPase activation

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Supplementary files

Article information


Submitted
06 Apr 2011
Accepted
16 May 2011
First published
31 May 2011

Chem. Commun., 2011,47, 7521-7523
Article type
Communication

A luminescent oxygen channeling biosensor that measures small GTPase activation

B. Niebel, B. Weiche, A. L. Mueller, D. Y. Li, N. Karnowski and M. Famulok, Chem. Commun., 2011, 47, 7521
DOI: 10.1039/C1CC11944C

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