Issue 23, 2011

Active thionium species mediated functionalization at the 2α-position of indole derivatives

Abstract

A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2α-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.

Graphical abstract: Active thionium species mediated functionalization at the 2α-position of indole derivatives

Supplementary files

Article information

Article type
Communication
Submitted
22 Mar 2011
Accepted
26 Apr 2011
First published
10 May 2011

Chem. Commun., 2011,47, 6728-6730

Active thionium species mediated functionalization at the 2α-position of indole derivatives

K. Higuchi, M. Tayu and T. Kawasaki, Chem. Commun., 2011, 47, 6728 DOI: 10.1039/C1CC11645B

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