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Issue 20, 2011
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Noteworthy observations accompanying synthesis of the apoptolidin disaccharide

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Abstract

A stereoselective synthesis of the apoptolidin disaccharide is reported. The key chemistry features a new transformation utilizing a highly selective tetramethylalkoxyalanate[V]-directedsyn-methylation of a vinylogous ester, isolation of a hydrate of a 2-keto sugar, an eco-friendly radical cleavage of a bromomethyl group, and an efficient preparation of a fluorodisaccharidevia the use of XtalFluor-E.

Graphical abstract: Noteworthy observations accompanying synthesis of the apoptolidin disaccharide

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Publication details

The article was received on 13 Mar 2011, accepted on 29 Mar 2011 and first published on 18 Apr 2011


Article type: Communication
DOI: 10.1039/C1CC11448D
Citation: Chem. Commun., 2011,47, 5858-5860
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    Noteworthy observations accompanying synthesis of the apoptolidin disaccharide

    M. Srinivasarao, T. Park, Y. Chen and P. L. Fuchs, Chem. Commun., 2011, 47, 5858
    DOI: 10.1039/C1CC11448D

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