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Issue 19, 2011
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A mirror-image tetramolecular DNA quadruplex

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Abstract

L-DNA, the mirror image of natural DNA forms structures of opposite chirality. We demonstrate here that a short guanine rich L-DNA strand forms a tetramolecular quadruplex with the same properties as a D-DNA strand of identical sequence, besides an inverted circular dichroism spectra. L- and D-strands self exclude when mixed together, showing that the controlled parallel self-assembly of different G-rich strands can be obtained through L-DNA use.

Graphical abstract: A mirror-image tetramolecular DNA quadruplex

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Article information


Submitted
04 Mar 2011
Accepted
25 Mar 2011
First published
11 Apr 2011

Chem. Commun., 2011,47, 5437-5439
Article type
Communication

A mirror-image tetramolecular DNA quadruplex

P. L. T. Tran, R. Moriyama, A. Maruyama, B. Rayner and J. Mergny, Chem. Commun., 2011, 47, 5437
DOI: 10.1039/C1CC11293G

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