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Issue 21, 2011
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Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

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Abstract

Carbohydrate derivatisation and glycocluster formation are both known to enhance avidity for lectin binding. Using a plant toxin and human adhesion/growth-regulatory lectins (inter- and intrafamily comparisons) the effect of their combination is examined. In detail, aromatic substituents were introduced at the 2-N or 3′-positions of N-acetyllactosamine and the products conjugated to two types of calix[n]arenes (n = 4, 6) viathiourea-linker chemistry.

Graphical abstract: Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

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Publication details

The article was received on 26 Feb 2011, accepted on 31 Mar 2011 and first published on 26 Apr 2011


Article type: Communication
DOI: 10.1039/C1CC11163A
Citation: Chem. Commun., 2011,47, 6126-6128

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    Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

    S. André, C. Grandjean, F. Gautier, S. Bernardi, F. Sansone, H. Gabius and R. Ungaro, Chem. Commun., 2011, 47, 6126
    DOI: 10.1039/C1CC11163A

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