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Issue 17, 2011
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Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

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Abstract

Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer's disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

Graphical abstract: Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

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Publication details

The article was received on 24 Dec 2010, accepted on 11 Mar 2011 and first published on 25 Mar 2011


Article type: Communication
DOI: 10.1039/C0CC05764A
Citation: Chem. Commun., 2011,47, 5070-5072
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    Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

    F. Mito, T. Yamasaki, Y. Ito, M. Yamato, H. Mino, H. Sadasue, C. Shirahama, K. Sakai, H. Utsumi and K. Yamada, Chem. Commun., 2011, 47, 5070
    DOI: 10.1039/C0CC05764A

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