Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA

Puja Prasad; Imran Khan; Pijus K. Sasmal; Debasis Koley; Paturu Kondaiah; Akhil R. Chakravarty

doi:10.1039/C0CC05386D

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Planar triazinium cations from VO²⁺-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA†

Puja Prasad,^a Imran Khan,^b Pijus K. Sasmal,^a Debasis Koley,^a Paturu Kondaiah^b and Akhil R. Chakravarty*^a

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* Corresponding authors

^a Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India
E-mail: arc@ipc.iisc.ernet.in
Fax: +91 80-23600683
Tel: +91 80-22932533

^b Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India

Abstract

Planar triazinium cationic species, from VO²⁺-assisted cyclization of 1-(2-thiazolylazo)-2-naphthol, shows efficient DNA intercalative binding, visible light-induced anaerobic plasmid DNA photocleavage activity and photocytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway with selective localization of the compound in the nucleus as evidenced from the nuclear staining and confocal imaging.

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Article information

DOI: https://doi.org/10.1039/C0CC05386D
Article type: Communication
Submitted: 06 Dec 2010
Accepted: 03 Feb 2011
First published: 21 Feb 2011

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Chem. Commun., 2011,47, 3954-3956

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Planar triazinium cations from VO²⁺-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA

P. Prasad, I. Khan, P. K. Sasmal, D. Koley, P. Kondaiah and A. R. Chakravarty, Chem. Commun., 2011, 47, 3954 DOI: 10.1039/C0CC05386D

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