Issue 13, 2011
From the journal:

Chemical Communications

Dynamic kinetic resolution in the stereoselective synthesis of 4,5-diaryl cyclic sulfamidates by using chiral rhodium-catalyzed asymmetric transfer hydrogenation†

Juae Han,ab   Soyeong Kangab  and  Hyeon-Kyu Lee*ab  

* Corresponding authors

a Drug Discovery Division, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong, Daejeon 305-600, Korea

b Medicinal and Pharmaceutical Chemistry Major, University of Science and Technology, 113 Gwahango, Yuseong, Daejeon 305-333, Korea
E-mail: leehk@krict.re.kr
Fax: +82 42 8607160
Tel: +82 42 8607016

Abstract

The dynamic kinetic resolution of 4,5-diaryl cyclic sulfamidate imines was achieved via asymmetric transfer hydrogenation using a HCO2H/Et3N mixture as the hydrogen source and chiral Rh catalysts (R,R)- or (S,S)-RhCl(TsDPEN)Cp* affording the corresponding cyclic sulfamidates in good yields with up to >20 ∶ 1 dr and up to >99% ee.

Graphical abstract: Dynamic kinetic resolution in the stereoselective synthesis of 4,5-diaryl cyclic sulfamidates by using chiral rhodium-catalyzed asymmetric transfer hydrogenation

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Article information

DOI
https://doi.org/10.1039/C0CC05289B
Article type
Communication
Submitted
30 Nov 2010
Accepted
31 Jan 2011
First published
18 Feb 2011

Chem. Commun., 2011,47, 4004-4006

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Dynamic kinetic resolution in the stereoselective synthesis of 4,5-diaryl cyclic sulfamidates by using chiral rhodium-catalyzed asymmetric transfer hydrogenation

J. Han, S. Kang and H. Lee, Chem. Commun., 2011, 47, 4004 DOI: 10.1039/C0CC05289B

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