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Issue 7, 2011
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Protein–ligand binding investigated by a single nanoparticleTERS approach

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Abstract

We report TERS imaging of individual 50 nm, biotin-labeled gold nanoparticles bound to a streptavidin-derivatized glass slide. Individual gold nanoparticles detected by a nanoparticle TERS tip generate Raman enhancements in both the biotin and streptavidin signals. These results indicate that nanoparticles are capable of investigating nanoscale spatial and chemical environments with non-resonant Raman enhancements.

Graphical abstract: Protein–ligand binding investigated by a single nanoparticle TERS approach

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Supplementary files

Article information


Submitted
19 Nov 2010
Accepted
10 Dec 2010
First published
04 Jan 2011

Chem. Commun., 2011,47, 2065-2067
Article type
Communication

Proteinligand binding investigated by a single nanoparticle TERS approach

S. L. Carrier, C. M. Kownacki and Z. D. Schultz, Chem. Commun., 2011, 47, 2065
DOI: 10.1039/C0CC05059H

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