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Issue 8, 2011
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Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

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Abstract

Two complementary formats for kinase inhibitor screening are presented in which peptide-modified gold nanoparticles are enzymatically phosphorylated and rapidly aggregate on a surface or in solution by action of phosphospecific antibodies. The simple and rapid colourimetric response of the assays makes them an attractive approach for drug-screening applications.

Graphical abstract: Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

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Article information


Submitted
11 Nov 2010
Accepted
21 Dec 2010
First published
18 Jan 2011

Chem. Commun., 2011,47, 2249-2251
Article type
Communication

Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

S. Gupta, H. Andresen and M. M. Stevens, Chem. Commun., 2011, 47, 2249
DOI: 10.1039/C0CC04903D

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