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Issue 8, 2011
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Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

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Abstract

Two complementary formats for kinase inhibitor screening are presented in which peptide-modified gold nanoparticles are enzymatically phosphorylated and rapidly aggregate on a surface or in solution by action of phosphospecific antibodies. The simple and rapid colourimetric response of the assays makes them an attractive approach for drug-screening applications.

Graphical abstract: Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

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Publication details

The article was received on 11 Nov 2010, accepted on 21 Dec 2010 and first published on 18 Jan 2011


Article type: Communication
DOI: 10.1039/C0CC04903D
Citation: Chem. Commun., 2011,47, 2249-2251

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    Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

    S. Gupta, H. Andresen and M. M. Stevens, Chem. Commun., 2011, 47, 2249
    DOI: 10.1039/C0CC04903D

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