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Issue 5, 2011
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Bead diffusion assay for discovering antimicrobial cyclic peptides

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Abstract

A combinatorial library of 15 536 cyclic decapeptide analogues of tyrocidine A and gramicidin S was prepared on photocleavable TentaGel beads. The beads were photolyzed without solvent, and spread onto an agar plate inoculated with bacterial lawn. Clear zones were formed around beads carrying antimicrobially active peptides such as E18 c(kVOrnLfThiYOrnLq), which inhibited growth of B. subtilis and selected MRSA strains.

Graphical abstract: Bead diffusion assay for discovering antimicrobial cyclic peptides

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Article information


Submitted
28 Oct 2010
Accepted
22 Nov 2010
First published
10 Dec 2010

Chem. Commun., 2011,47, 1434-1436
Article type
Communication

Bead diffusion assay for discovering antimicrobial cyclic peptides

V. S. Fluxà, N. Maillard, M. G. P. Page and J. Reymond, Chem. Commun., 2011, 47, 1434
DOI: 10.1039/C0CC04670A

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